Lipids are no longer seen as molecules that only provide membrane structure and organization. Due to their amphipathic nature, lipids are localized both on the surface and internally in membranes in the cell, and at these locations, trigger signaling pathways by interacting with soluble proteins, typically through lipid- interacting domains and motifs. More importantly, interconversion of lipid species in these compartments is fundamental, not only by sustaining signaling but also by contributing to signaling pathways that link protein receptors with intracellular effectors. With...