Highlighting the importance of scientific progress in understanding the neurodevelopmental origins of psychopathology, this study presents the work of some of the most talented researchers in the field. Its chapters illustrate the interactional processes that characterize the genesis and maturation of the brain. They demonstrate how constitutional vulnerability to mental disorder can arise from the interplay of multiple factors. Dante Cicchetti and Elaine Walker offer invaluable perspectives for the pursuit of further research.