This book provides multidisciplinary reviews of the mechanism of actio n and uses of methotrexate in the treatment of cancer, psoriasis, gyne cologic and inflammatory diseases. The intended audience includes clin icians involved in the care of patients suffering from oncologic, gyne cologic, rheumatic diseases as well as scientists involved in research into the pathogenesis and treatment of these diseases. This book prov ides a single, state-of-the-art source for information regarding the m echanism and use of methotrexate in many different areas of medicine.