This study was designed to compare the pharmacokinetic parameters of Levofloxacin in healthy volunteers and in human patients suffering from typhoid fever. The study was conducted in six healthy male volunteers and six male patients suffering from typhoid fever between the age of 25- 40 years. The patients were considered as group A and healthy volunteers were considered as group B. Both groups were treated with Levofloxacin 500mg tab orally. 5ml Blood samples were collected at 0, 0.25, 0.5, 1, 2, 3, 6, 12, 24, 36 & 72 hr from vein after oral administration. Plasma was separated by...

Silymarin is a purified extract from milk thistle (Silybum marianun (L.) Gaertn), composed of a mixture of isomeric flavonolignans: silybin (its main, active component), isosilybin, silydianin and silychristin. This extract has been empirically used as a remedy for almost 2000 years, and remains being used as a medicine for many types of acute and chronic liver diseases. Despite its routinely clinical use as hepatoprotectant, the mechanisms underlying its beneficial effects remain largely unknown. The purpose of this study was to investigate the pharmacokinetics and bioaequivalence of two...

The Percutaneous nephrolithotomy (PCNL)is now become a fast and routine procedure for nephrolithiasis in most urological centres. The aim of study is to assess the changes in standard procedure and its outcome on patient morbidity. As we discussed that the conventional procedure need the placement of nephrostomy tube, so we assess , is the nephrostomy tube, is really worthwhile after procedure? if needed, is it necessary to put the large bore tube instead of small bore tube. we compare, the outcome of large bore, with small bore, and tubeless PCNL. we comes on conclusion, that patients with...