Certain drugs having poor solubility, degradation in the alkaline pH, absorbed from the proximal part of Gastrointestinal Tract and causes irritation in the stomach. Due to this reason, drug should not achieve 100% bioavailability. To overcome these, Gastroretentive drug delivery system is a promising approach for achieving prolonged and predictable drug delivery profile. Floating drug delivery is an attempt which has been made to retained the drug in the stomach as a way of increasing retention time. Such type of novel drug delivery reduces the dosing frequency which is patient compliant and...
Certain drugs having poor solubility, degradation in the alkaline pH, absorbed from the proximal part of Gastrointestinal Tract and causes irritation ...