Chalcones and 1,5-benzothiazepines derived from 4-isobutyl acetophenone having a variety of pharmacophores could be successfully synthesized in good yield, purified, and characterized by spectral studies. These compounds were evaluated for antimicrobial and cytotoxic activities. It was observed from the results that the chalcones possessed better antibacterial activity while the benzothiazepines possessed better antifungal activity. In each case, the contribution of electron-withdrawing groups is remarkable in enhancing the antibacterial or antifungal activity The cytotoxic activity as...