Azadirachta Indica A.juss, belonging to the family of meliaceae is an important medicinal plant used in the traditional system of medicine to treat various disease for the betterment of mankind . It is commonly known as Indian neem or margosa tree which is evergreen and cultivated in various part of Indian and sub-continent. Almost every part of the tree is used to treat various disease. The leaves are alternate in arrangement and consist of several leaflets in them with separated edge. Flowers are soft and white in colour. The first is oval, round and skinned. Neem is used in the treatment...

The aim of the present study is to perform invitro - invivo correlation for the formulation containing paracetamol and tramadol.To conduct invitro - invivo correlation a validated bioanalytical HPLC method is required.Therefore a HPLC method is to be develop and validated in plasma.Inoder to conduct invitro - invivo correlation formulation with 3 different release rates are required.These formulations will be subjected to invitro dissolution rate and invivo bioavailability.

Readily available Tablet dosage forms dissolve and disintegrate quickly, allowing the medicine to be released and begin working quickly. In the stomach, it should decay or disintegrate quickly. Environmental variables such as temperature and humidity should have little effect on it. Be produced at a cheap cost utilizing standard processing and packing machinery. After oral administration, it should leave minimal, very little, or no residue in the mouth. It causes the medication to dissolve and absorb quickly, potentially leading to a rapid beginning of effect. To offer an appropriate when...