There have been numerous COVID-19 vaccines introduced with various efficacy and safety profiles. The severity and reactogenicity of the COVID-19 vaccine in our community has received very little attention to date, and many people have expressed concerns about its safety. The purpose of this study was to evaluate the severity of symptoms and thrombotic side effect after the first dose of AstraZeneca COVID-19 vaccineand the risk factors associated with severe side effects among Libyans in the west of the country.