A Golden Rule in dental practice if endodontology is described and obturate 3 dimensionally. there are many challenging cases in daily basis such as open apex, divergent root Walls that are susceptible to fracture and frequent periapical reason.Many different materials have been advocated for use as apexification and each has specific advantage and disadvantage, However from the biological perspective of healing the apex. For open apex treatment, Apexification process may be use as a 1st line of treatment.Recent Material like MTA and BIODENTINE are promising and play an important role in...