This textbook emphasizes the role and significance of prognostic markers in Oral squamous cell carcinoma. The significance of prognosis in squamous cell carcinoma (SCC) lies in its ability to provide valuable information about the likely course of the disease and its outcomes. By considering the prognosis of squamous cell carcinoma, healthcare professionals can provide personalized care, optimize treatment approaches, and support patients in making informed decisions throughout their journey with the disease.