In this study we observed efficacy and safety parameters in both CS and PTZ group. Statistical analysis showed that both the groups were equally effective and safe as an empirical antibiotic therapy for infection in CKD patients and there is no significant difference. CS may be an appropriate choice in case of dosing frequency as it has twice daily dosing. For patients with elevated liver enzymes CS maybe an appropriate choice. Patient with blood disorder or increased prothrombin time PTZ is an appropriate choice. When addressing dose adjustment, PTZ group had more inappropriate dosing...