The objective of the present study was to develop floating alginate beads of Propranolol hydrochloride for oral use with a point of view to treat hypertension. Propranolol is retained in the stomach for a prolonged period of time. The drug is stable and easily absorbable in an acidic medium. Its elimination half-life is about 3-6 hrs and its bioavailability is up to 25 %. Among the various approaches to achieve gastric retention time, the gastric floating drug delivery system is one approach selected to prolong the floating behavior of the alginate beads. For this purpose sodium alginate was...

Elderly persons are more vulnerable to depression. We conducted this study to estimate the prevalence of depression and to study the association of depression with socio-demographic and clinical variables among elderly persons in a rural community. The aim of the present study was to assess depression in geriatric patients using the geriatric depression scale: short form (GDS: SF -15) and to find whether psychosocial factors, demographic factors,lifestyle factors and socioeconomic factors are associated with depression, and to assess the level of social support in relation to depression.

All the formulations were prepared by direct compression method. The prepared tablets of all the formulations were evaluated for physical characters, assay, in-vitro drug release, swelling index, hardness and friability. The main aim was to optimize the formulation for 1-12 hours in-vitro release. Optimized formulation F9 containing chitosan and xanthan gum in 1:1 ratio shows better drug release up to 12hours was consider as the best product with respect to in-vitro drug release for 12 hours release action and improved site-specific action. The results showed that the drug release rate was...

Six formulations of modified pulsincap of Indomethacin were developed by using various grades and ratios by using Hydroxy propyl methyl cellulose K-100M, CCS as rate controlling polymers. Magnesium sterate and talc are the other components used. Blends were evaluated for various parameters such as bulk density, tapped density,angle of repose, Hausners ratio, Carr's index. Capsules were evaluated for their physical appearance,drug content, % weight variation and Invitro drug release. All the physico chemical properties are with in the acceptable limits. Based on the results, formulation F6...

A Visible Spectrophotometric method has been developed and validated for the quantitative measurement of Bempedoic acid in bulk and tablet dosage forms. The process is based on the production of a colored complex in the presence of Ferric chloride between Bempedoic acid and MBTH (3-methyl-2-benzothiazolinone Hydrazone). At 663 nm, the colored complex was spectrophotometrically measured. The correlation coefficient (r2) of 0.999 revealed that the approach is linear in the concentration range of 10-60 µg/mL. It was discovered that the limits of detection (LOD) and quantitation (LOQ) were 2.169...

Knee osteoarthritis related disability is high in the elderly population. Patients feel difficulty in walking/ jogging, an important and easy option to reduce the risk of cardiovascular disease. Stiffness, pain, other knee related symptoms may limit the patients' functional status and recreational activities. Thus, these individuals suffer from progressive impact on their activities of daily living and leads to loss in leisure, social life, sleeping quality and thus decrease in their quality of life. Worse QoL in patients with knee OA is also associated with severity of clinical...

The Corona virus Disease 2019 (COVID-19) is a pandemic that emerged for the first time in Wuhan, China, and spreads all over the world between December 2019 and early 2020. The state of lock-down in many parts of the world, which are contributing largely to the global economy has led to the halting of services and products. Along with the economy impacts, the ever-increasing morbidity and mortality due to COVID-19 is the biggest setback. The prevalence of epidemics accentuates or creates new stressors. The aim of our study is to determine the effect of the COVID-19 pandemic on mental health...