Systemic administration of antimicrobial agents produces therapeutic concentration at the site of infection, but for short periods of time. Invariably, forcing the use of repeated doses, for a prolonged period results in drug toxicity and acquired bacterial resistance. In such cases, local drug delivery systems play a major role in the management of periodontal diseases. Irrigating systems, fibers, gels, strips, films, microparticles, nanoparticles, and low-dose antimicrobial agents are some of the local drug delivery systems (LDDS) available in the field, which aim to deliver antimicrobial...