Bone destruction is central to conditions like osteoporosis, rheumatoid arthritis, and cancers with bone metastases. It results from an imbalance between bone resorption by osteoclasts and formation by osteoblasts. Osteoclast activity is regulated by the RANK/RANKL/OPG axis, where an increased RANKL/OPG ratio promotes osteoclastogenesis. Inflammatory cytokines (e.g., TNF- , IL-1, IL-6) enhance RANKL expression and osteoclast survival. In cancer, tumor-derived factors like PTHrP and prostaglandins further drive RANKL-mediated bone loss. Bone resorption releases growth factors such as TGF-beta,...
Bone destruction is central to conditions like osteoporosis, rheumatoid arthritis, and cancers with bone metastases. It results from an imbalance betw...
Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defence during inflammation and infections. Neutrophils, are myeloid-derived, antimicrobial phagocytes. The polymorphonuclear leukocyte is the most important phagocytic cell in the defence of the host against acute bacterial infection. During bacterial invasion, microorganisms evoke an inflammatory response that recruits neutrophils from the circulation into the tissues. Therefore, neutrophils destroy the microorganisms by a series of mechanisms, mainly phagocytosis, release of antimicrobial...
Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defence during inflammation and infections. Neutrophi...
Periodontal diseases are inflammatory diseases in which microbial etiologic factors induce a series of host responses that mediate inflammatory events. Physiologic inflammation is a well-orchestrated network of cells, mediators and tissues. Cytokines are signaling proteins that help control inflammation in your body. Cytokines have important roles in chemically induced tissue damage repair, in cancer development and progression, in the control of cell replication and apoptosis, and in the modulation of immune reactions such as sensitization. Cytokines are major regulators of innate and...
Periodontal diseases are inflammatory diseases in which microbial etiologic factors induce a series of host responses that mediate inflammatory events...
La destruction osseuse est au coeur de pathologies telles que l'ostéoporose, la polyarthrite rhumatoïde et les cancers avec métastases osseuses. Elle résulte d'un déséquilibre entre la résorption osseuse par les ostéoclastes et la formation par les ostéoblastes. L'activité des ostéoclastes est régulée par l'axe RANK/RANKL/OPG, où une augmentation du rapport RANKL/OPG favorise l'ostéoclastogenèse. Les cytokines inflammatoires (par exemple TNF- , IL-1, IL-6) augmentent l'expression de RANKL et la survie des ostéoclastes. Dans le cas du cancer, des facteurs dérivés de la...
La destruction osseuse est au coeur de pathologies telles que l'ostéoporose, la polyarthrite rhumatoïde et les cancers avec métastases osseuses. El...
Die Zerstörung von Knochen spielt eine zentrale Rolle bei Erkrankungen wie Osteoporose, rheumatoider Arthritis und Krebserkrankungen mit Knochenmetastasen. Sie entsteht durch ein Ungleichgewicht zwischen der Knochenresorption durch Osteoklasten und der Knochenbildung durch Osteoblasten. Die Osteoklastenaktivität wird durch die RANK/RANKL/OPG-Achse reguliert, wobei ein erhöhtes RANKL/OPG-Verhältnis die Osteoklastogenese fördert. Entzündungszytokine (z. B. TNF- , IL-1, IL-6) verstärken die RANKL-Expression und das Überleben der Osteoklasten. Bei Krebserkrankungen treiben vom Tumor...
Die Zerstörung von Knochen spielt eine zentrale Rolle bei Erkrankungen wie Osteoporose, rheumatoider Arthritis und Krebserkrankungen mit Knochenmetas...
