Cbl proteins are important ubiquitous regulators of various biological processes ranging from defense against infection to bone formation, and the list of these processes grows continuously. There are three Cbl-family proteins in mammals, which exhibit disparate biological effects. Furthermore, all metazoans appear to have Cbl-like proteins playing important regulatory roles in these organisms ranging from round worms and flies to amphibians and birds. One of the interesting peculiarities of the Cbl-mediated regulation is its dependence on multiple molecular mechanisms, which makes this...
Cbl proteins are important ubiquitous regulators of various biological processes ranging from defense against infection to bone formation, and the lis...