This new book presents important research from leaders in the field. It is pointed out that practically any stimulus capable of causing injury to a tissue or organ can, when applied close to the threshold of damage, activate endogenous protective mechanisms thus potentially lessening the impact of subsequent, more severe stimuli in the brain tissue. The phenomenon of ischemic tolerance is explained with the help of different experimental models constituting the main pharmacological targets to induce preventive neuroprotection. Deep insights are given into the main molecular mechanisms for...

In recent years, a substantial number of imaging studies hav addressed the neuronal processes underlying recovery after stroke. Although difficult to achieve, several longitudinal studies assessed both clinical recovery and imaging patterns over time and give important inside into the plasticity of the stroked brain. This tendency is supported by the fact that it has become possible to depict biological processes at the cellular and molecular level. These new research methods use magnetic resonance imaging (MRI), positron emission tomography (PET), near-infrared optical imaging, scintigraphy,...

Stroke represents a clinical syndrome of rapid onset of focal or sometimes global cerebral deficit with a vascular cause, lasting more than 24 hours or leading to death. Eighty per cent of all strokes are ischaemic, 15 percent are due to intracerebral haem

Focuses on advances in imaging and mapping strategies to study the brain's structure, function and the relationship between both, from the whole brain to the molecular and cellular tissue level in order to improve the understanding of normal and disease pr