With the Wife Project complete, Don settles into a new job and married life in New York. But it's not long before certain events are taken out of his control and it's time to embark on a new project. As he tries to get to grips with the requirements of starting a family, his unusual research style gets him into trouble. To make matters worse, he has invited his closest friend to stay with them, but Gene is not exactly the best model for marital happiness.