Dental caries and trauma are the most common challenges to the integrity of a tooth as it matures. If this occurs prior to complete root formation and apical closure, normal root development is halted. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. Regenerative endodontic methods have the potential for regenerating both pulp and dentin tissues and therefore may offer an...