Background: This study was designed to assess right ventricular (RV) systolic function in cancer patients. Methods and Results: Left ventricle (LV) and free-wall RV longitudinal strain were analysed prior and after 6 months of treatment (at 68 patients), using a vendor-independent software, together with left ventricular ejection fraction (LVEF), tricuspid annulus plane systolic excursion and RV fractional area change. Cancer therapy-related cardiac dysfunction was defined as a LVEF drop of >10% to <53%. Both LVEF fraction (59±7% vs. 55±8%, p<0.0001) and LV longitudinal strain (-19.7±2.5%...