Minimally invasive surgery has to be considered a true reality in periodontal regenerative surgery. Several clinical trials have shown its efficacy and predictability in the treatment of intrabony defects. The clinical efficacy is consistently associated with a very low morbidity both during surgery and in the post-operative healing period. The minimally invasive surgical procedures require a specific training and the use of dedicated instruments and materials to be successfully applied to the treatment of intrabony defects. Applying microsurgical concepts in the field of periodontal surgery...