The treatment of periodontal disease has evolved from just fighting bacteria to combined efforts to eliminate the offending microorganisms, to arrest the progression of tissue damage and to regenerate lost tissues. Tissue engineering strategy for periodontal regeneration exploits the regenerative capacity of cells residing within the periodontium and involves the use of such cells grown within a three-dimensional construct in combination with signalling molecules, and subsequent implantation into the defect. The concept of tissue engineering is intimately associated with the events occurring...

Platelet concentrates play a crucial role in periodontal regeneration. They are prepared from the patient's own blood, where activated platelets are enclosed within a fibrin matrix scaffold and release growth factors and cytokines that play a key role in tissue regeneration. This includes cell proliferation and differentiation, extracellular matrix synthesis, chemotaxis, and angiogenesis. Platelets have been confirmed to aid in regeneration due to their pool of growth factors that are responsible for neovascularization, collagen synthesis, cell division, cell differentiation, induction, and...