The present study was carried out to develop sustained release matrix tablets of mosapride citrate dihydrate. Matrix tablets of mosapride citrate dihydrate with two different viscosity grades of hydroxypropyl methylcellulose were prepared by dry granulation and direct compression method and evaluated.The study demonstrated that combination of HPMC K4M and HPMC mosapride citrate dihydrate. This can be expected to reduce the frequency of administration and decrease the dose - dependent side effects associated with repeated administration of conventional mosapride citrate dihydrate tablets. The...