This book constitutes the refereed proceedings of the 5th International Conference on Applied Machine Learning and Data Analytics, AMLDA 2022, held in Reynosa, Tamaulipas, Mexico, during December 22-23, 2022. The 16 full papers and 4 short papers included in this book were carefully reviewed and selected from 89 submissions. They were organized in topical sections as follows: Machine learning, Healthcare and medical imaging informatics; biometrics; forensics; precision agriculture; risk management; robotics and satellite imaging.