In present work a model corn zein-based medicated chewing gum for motion sickness was developed. A modified fusion method suggested by Mc Gowan and co workers was used for the preparation of corn zein MCG. Based on the results of RSM (Response surface methodology) studies corn zein concentration of 57.6 % w/w was optimized and used in the current study. Various formulations of corn zein MCG samples were prepared varying only the plasticizer content (MCG-1 to MCG-10). The corn zein MCG formulations were prepared using various plasticizers like (A) PEG 4000, (B) PEG 200, (C) PEG-300, (D)...