The most common type of ovarian cancer is epithelial ovarian cancer (EOC) worldwide. The current standard treatment consists of complete Cytoreductive surgery with platinum-based chemotherapy. HIPEC with Cisplatin is delivered after CRS at 410-430 C and it has become the advanced treatment modality with survival benefit. The tumor and the surrounding microenvironment (TME) are closely related and interact constantly. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis, and inducing peripheral immune tolerance, while the immune cells in...