Esophageal cancer is unique among the gastrointestinal tract malignancies because it embodies two distinct histopathological types, squamous cell carcinoma and adenocarcinoma. Incidence is increasing gradually worldwide. Although it seems appropriate to individualize the treatment of these tumours, often they are managed as a single entity. Unfortunately, present-day therapeutic interventions have had little impact on survival, as evidenced by the equivalence of incidence and mortality rates. A more thorough understanding of the initiating events, the molecular biologic basis, and treatment...

The most common type of ovarian cancer is epithelial ovarian cancer (EOC) worldwide. The current standard treatment consists of complete Cytoreductive surgery with platinum-based chemotherapy. HIPEC with Cisplatin is delivered after CRS at 410-430 C and it has become the advanced treatment modality with survival benefit. The tumor and the surrounding microenvironment (TME) are closely related and interact constantly. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis, and inducing peripheral immune tolerance, while the immune cells in...

Speiseröhrenkrebs ist unter den bösartigen Erkrankungen des Magen-Darm-Trakts einzigartig, da er zwei unterschiedliche histopathologische Typen umfasst: Plattenepithelkarzinome und Adenokarzinome. Die Inzidenz nimmt weltweit allmählich zu. Obwohl es sinnvoll erscheint, die Behandlung dieser Tumoren zu individualisieren, werden sie häufig als eine Einheit behandelt. Leider haben sich die heutigen therapeutischen Maßnahmen kaum auf die Überlebensrate ausgewirkt, wie die Gleichwertigkeit der Inzidenz- und Mortalitätsraten zeigt. Ein besseres Verständnis der auslösenden Ereignisse, der...

Ovarian cancer (OC) is the most lethal gynecological cancer worldwide. Complete cytoreduction with platinum based chemotherapy is the standard of care. Despite this, many patients recur predominantly in the peritoneal cavity. With advent of HIPEC, 5-yr survival has improved significantly. PCI is a major determinant for survival. Surgical PCI as advocated by Paul Sugarbaker provides a systematic and region wise assessment of disease. One of the indications for Neo-adjuvant chemotherapy is high PCI especially bulky upper abdomen disease including the sub diaphragmatic region and pleural...

Quality assurance is defined as "Complete set of systematic actions that are required to achieve a treatment result that meets a certain standard". To achieve this standard, there is a need to formulate a minimum standard of care, define an acceptable level of variation in treatment outcome and identify factors which are crucial to achieve this standard. The ultimate goal is to improve treatment outcome.Quality assurance measures at this institute include well defined Protocol based patient Pathways, standardization of Surgical Procedure steps, Prospective Computerized Clinical Database...

Ovarian carcinoma is generally diagnosed at an advanced stage. Any gross peritoneal disease outside pelvis more than 2 cm in size is staged as FIGO stage IIIc. It encompasses a spectrum of disease from solitary tumor deposit anywhere in abdomen to diffuse peritoneal metastases resulting in a frozen abdomen. The prognosis of the patients across this spectrum vary widely. Therefore, there is a need to validate a score which can precisely prognosticate a patient with advanced ovarian carcinoma.The aim of surgery is to achieve optimal cytoreduction i.e. CCS 0/1. PCI is known to have a correlation...

Peritoneal metastasis from appendiceal, colorectal, ovarian, gastric and peritoneal cancer itself presents with an aggressive biology and clinical behavior. The majority of patients develop peritoneal carcinomatosis (PC) relatively early in the disease. The prognosis of the patients of ovarian cancer and colorectal cancer with PC has been shown to improve significantly after the cytoreductive surgery and Hyperthermic intraperitoneal chemotherapy (CRS+HIPEC). Available literature suggests that serious postoperative complications not only affect patient recovery but may also delay the adjuvant...

Qualitätssicherung wird definiert als "Gesamtheit der systematischen Maßnahmen, die erforderlich sind, um ein Behandlungsergebnis zu erzielen, das einem bestimmten Standard entspricht". Um diesen Standard zu erreichen, ist es notwendig, einen Mindeststandard für die Versorgung zu formulieren, eine akzeptable Schwankungsbreite bei den Behandlungsergebnissen zu definieren und Faktoren zu ermitteln, die für das Erreichen dieses Standards entscheidend sind. Oberstes Ziel ist die Verbesserung des Behandlungsergebnisses.Zu den Qualitätssicherungsmaßnahmen an diesem Institut gehören gut...