Series of substituted Synthesis of sub -N-sub-1,3,4-thiadiazol-2-amine derivatives (3a-t) containing 1,3,4 - thiadiazol moiety were designed and synthesized by conventional and microwave as a green chemistry method. Compound 3b showed potent activity against potent inhibitors of NUDTs silence hormone signaling in breast cancer (PDB Code-5NQR) for anti-cancer activity and 3b showed potent activity against receptor Crystal structure of Rhodostomin ARLDDL mutant (PDB Code-3UCI) for antibacterial activity, Compound 3f showed potent activity against Snapshots of the RNA processing factor SCAF8...