Oral submucous fibrosis(OSMF) is a chronic disease of insidious onset featuring the deposition of fibrous tissue in the submucous layer of the palate, fauces, cheek, lips, pharynx and esophagus resulting in trismus and disability. The incidence of OSMF is still rising alarmingly and there is a dire need to search for an effective and safe remedy because of lack of present therapies to either provide a complete cure or treat the patients at the cost of adverse effects. All the available treatments give only symptomatic relief which are of short duration.Comprehensive search of scientific...