A simple, precise and rapid stability-indicating HPLC assay method was developed for the simultaneous quantitative estimation of Paracetamol and Metoclopramide from their dosage form in the presence of degradation products. It involved 250 mm × 2.5mm, 5mi, hypersil, C18 column. The separation was achieved on simple gradient program. The mobile phase contains 7 ml of Triethylamine in 1000 ml of water, pH 4.0 + 0.02 adjusted with orthophosphoric acid and Methanol. The flow rate was maintained to 1 ml/min and column oven temperature was kept 25°C. The detector wavelength was 218 nm for...
A simple, precise and rapid stability-indicating HPLC assay method was developed for the simultaneous quantitative estimation of Paracetamol and Metoc...