Prostate cancer (PCa) and benign prostate hyperplasia (BPH) are the most common malignancy among men. On the other hand, insulin resistance (IR) is strongly associated with obesity and had an important role in the pathogenesis and raised complicating of many human diseases, such as PCa among men through various pathways such as changes in inflammation, oxidative stress and apoptosis. Hence, taking into consideration the combination of obesity, IR and some markers of tumor, pro-inflammatory and oxidative stress may demonstrated excellent indicator for early-stage risk of PCa among men. In the...