Oral Leukoplakia is the most common premalignant lesion of the oral cavity. The incidence of oral leukoplakia varies in different parts of the world. Its etiology is multifactorial, with tobacco being the most commonly associated risk factor. Clinically, it is observed in middle aged and older men and its prevalence increases with the advancement of age. Various attempts have been made over the years to find an effective treatment for oral leukoplakia. Along with various drugs, antioxidants such as vitamin A,C, E, lycopene and beta-carotene, have been tried so far. Amongst them, lycopene is...