L'utilisation des acides nucléiques circulants comme outils de diagnostic et/ou de pronostic en oncologie a été largement documentée. De même, en gynécologie et en obstétrique, le développement d'un outil de diagnostic prénatal non invasif, basé sur l'étude de ces biomarqueurs, a confirmé leur intérêt croissant dans cette discipline. Outre l'intérêt oncologique de ces fragments d'ADN libres, l'assistance médicale à la procréation a découvert un outil moléculaire facilement mesurable pour guider la gestion des couples infertiles. Plusieurs études ont porté sur les...
L'utilisation des acides nucléiques circulants comme outils de diagnostic et/ou de pronostic en oncologie a été largement documentée. De même, en...
Steven, Marcuse F., Louanjli, Noureddine, Zakaria, Mustafa
Description:Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An...
Description:Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remo...
Die Verwendung von zirkulierenden Nukleinsäuren als diagnostische und/oder prognostische Werkzeuge in der Onkologie ist weithin dokumentiert. Auch in der Gynäkologie und Geburtshilfe hat die Entwicklung eines nicht-invasiven Pränataldiagnostikwerkzeugs, das auf der Untersuchung dieser Biomarker basiert, ihr wachsendes Interesse an dieser Disziplin bestätigt. Abgesehen von dem onkologischen Interesse dieser freien DNA-Fragmente hat die assistierte Reproduktion ein leicht messbares molekulares Instrument entdeckt, das das Management unfruchtbarer Paare leitet. Mehrere Studien haben sich auf...
Die Verwendung von zirkulierenden Nukleinsäuren als diagnostische und/oder prognostische Werkzeuge in der Onkologie ist weithin dokumentiert. Auch in...
The use of circulating nucleic acids as diagnostic and/or prognostic tools in oncology has been widely documented. Likewise, in gynecology and obstetrics, the development of a non-invasive prenatal diagnostic tool, based on the study of these biomarkers, has confirmed their growing interest in this discipline. Apart from the oncological interest of these free DNA fragments, Assisted Reproduction has discovered an easily measurable molecular tool guiding the management of infertile couples. Several studies have focused on the microRNAs present in the ovarian follicle and their involvement in...
The use of circulating nucleic acids as diagnostic and/or prognostic tools in oncology has been widely documented. Likewise, in gynecology and obstetr...
The history of in vitro fertilization (IVF) goes back more than half a century. In 1959 the first birth in a nonhuman mammal resulting from IVF occurred, and in 1978 the world's first baby conceived by IVF was born. As medicine advanced, IVF was transformed from natural research to a stimulated clinical treatment. Reproduction is one of the naturally desired human purposes and is indispensable for the continuation of every society, However, approximately 8% of couples worldwide and 10% to 15% of those in developed countries have difficulty conceiving. In many societies, especially in low and...
The history of in vitro fertilization (IVF) goes back more than half a century. In 1959 the first birth in a nonhuman mammal resulting from IVF occurr...
