The Internet of Things is the evolutionary step of the Internet that creates a worldwide infrastructure interconnecting machines and humans. As the Internet became public in the early 1990s, the first wave of its exploitation and deployment was mainly focused on the impact to everyday services and applications that changed the known models for financial transactions, shopping, news feeding and information sharing. It was a revolution that digitised a wide range of services as we knew them, from banking and retail shopping to face-to-face communication and government services. The first two...

Malgré la facilité d'accès à la morphologie, le diagnostic se produit principalement à des stades avancés, en raison de l'absence d'outils de dépistage efficaces et peu coûteux et de biomarqueurs appropriés, qui permettent de diagnostiquer efficacement le cancer de la bouche et de prédire avec précision la progression des lésions précancéreuses vers le cancer. Le PRAME (Preferentially Expressed Antigen of Melanoma) est l'un de ces biomarqueurs, qui est un répresseur dominant de la vitamine A. La vitamine A ou son principal composant, l'acide rétinoïque (AR), est largement...

High morbidity and mortality in oral cancers, necessitates early diagnosis and effective management. Despite ease in morphological accessibility, diagnosis occurs mostly in advanced stages attributed to lack of effective and cheap screening tools and suitable biomarker, which can diagnose oral cancer effectively and can predict the progression of Oral precancer to Cancer accurately. PRAME (Preferentially Expressed Antigen of Melanoma) is one such biomarker, which is a dominant repressor of Vitamin A. Vitamin A or its chief component Retinoic Acid (RA) is extensively used these days for...

Trotz der leichten morphologischen Erkennbarkeit erfolgt die Diagnose meist erst in fortgeschrittenen Stadien, da es an wirksamen und kostengünstigen Screening-Instrumenten und geeigneten Biomarkern fehlt, die eine wirksame Diagnose von Mundhöhlenkrebs ermöglichen und das Fortschreiten von Mundhöhlenvorstufen zu Krebs genau vorhersagen können. PRAME (Preferentially Expressed Antigen of Melanoma) ist ein solcher Biomarker, bei dem es sich um einen dominanten Unterdrücker von Vitamin A handelt. Vitamin A bzw. sein Hauptbestandteil Retinsäure (RA) wird heutzutage aufgrund seiner Rolle bei...