Advancement and the progress made by the pharmaceutical industry that greatly contributed to treat the diseases, thus improving the quality of life. With the passage of the time researchers who are involved in the drug development industries focus on the alternative routes of administration of potentially capable pharmaceutical products and as well as to overcome defects that are associated with the oral route of administration. Though oral route is the most preferred route for the administration of major drugs but it possess certain draw backs such as, the first pass metabolism in the liver,...

Der Fortschritt und die Fortschritte der pharmazeutischen Industrie haben wesentlich zur Behandlung von Krankheiten und damit zur Verbesserung der Lebensqualität beigetragen. Im Laufe der Zeit konzentrieren sich die Forscher, die in der Arzneimittelentwicklung tätig sind, auf alternative Verabreichungswege für potenziell wirksame pharmazeutische Produkte und auf die Überwindung von Mängeln, die mit dem oralen Verabreichungsweg verbunden sind. Der orale Verabreichungsweg ist zwar der bevorzugte Weg für die Verabreichung wichtiger Medikamente, hat aber einige Nachteile, wie z. B. den...

Les avancées et les progrès réalisés par l'industrie pharmaceutique ont grandement contribué à traiter les maladies, améliorant ainsi la qualité de vie. Avec le passage du temps, les chercheurs qui sont impliqués dans les industries de développement de médicaments se concentrent sur les voies alternatives d'administration des produits pharmaceutiques potentiellement capables et ainsi que de surmonter les défauts qui sont associés à la voie orale d'administration. Bien que la voie orale soit la voie la plus privilégiée pour l'administration des principaux médicaments, elle...

The field of controlled drug delivery is undergoing rapid advances. The traditional prosthetic role of polymeric materials in medical devices is being supplemented by novel applications in the pharmacological and pharmaceutical areas. Because of the relative infancy of their field, there is much confusion in the scientific literature as to what ought to be called as "controlled" drug delivery. This term, as many others, is now well entrenched in the literature, but is nevertheless often misunderstood.

The present study was conducted to develop a GRDDS of rosuvastatin calcium and gymnema sylvestre using HPMC E50 and carbopol 934 of different polymer ratios. Out of the five different formulations, the formulation F3 was found to be an optimized formulation that has showed an excellent buoyant ability and a suitable drug release pattern. This could be advantageous in terms of increased bioavailability of rosuvastatin calcium and gymnema sylvestre increase the synergetic effect of the drug The developed GRDDS provides advantages of ease of preparation and sustained drug release for 12 h.