Platelet-rich fibrin (PRF) illustrates second generation of platelet concentrates, which has earning enormous attention in the upcoming years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, along with several other advantages over traditionally prepared platelet concentrates. Since its introduction, various protocols and modifications for PRF preparation have been proposed with different amounts of growth factors and other biomolecules necessary for wound healing and regenerative...