Niosomes are vesicular carriers in drug delivery system that are reported in seventies. They are formed by self -assembly of non -ionic surfactant and cholesterol upon hydration with aqueous media resulting in lamellar structures that encapsulates both polar and non polar drugs. In the present research work Montelukast sodium niosomes were prepared by using non -ionic surfactant span 60 and cholesterol in 1:1 concentration by thin film hydration method using rotary vaccum evaporator. The prepared Montelukast sodium niosomes were incorporated into the nanogel prepared by varying concentration...