Mast cells are found in all tissues of the oral cavity including dental pulp.Degranulation of mast cell releases proinflammatory mediators such as Tumor Necrosis factor-alpha, Chymase, Tryptase, Matrix Metalloproteinases (MMPs), Heparin, Histamine, various interleukins IL3, IL4, IL5, IL6, IL8, IL10, IL13,IL16 and cytokines contributing to the progress of periodontal disease.Thus the administration of locally or systemically acting mast cell stabilizer that inhibit mast cell degranulation may be a useful method to probe the role of mast cell in periodontitis.
Mast cells are found in all tissues of the oral cavity including dental pulp.Degranulation of mast cell releases proinflammatory mediators such as Tum...
Vaccine research in periodontal diseases is still in its infancy. The complexities in the etiopathogenesis of the periodontal diseases have been the prime obstacle in the hunt for vaccine. Among some 300 species of bacteria involved in subgingival plaque, 5-7 species have been implicated in the etiology of periodontitis which might play an important role as primary pathogens. A new milestone was achieved after the prime pathogens, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, were implicated in the etiology of periodontal disease. Now, vaccine research has shifted toward...
Vaccine research in periodontal diseases is still in its infancy. The complexities in the etiopathogenesis of the periodontal diseases have been the p...
La recherche de vaccins contre les maladies parodontales en est encore à ses débuts. La complexité de l'étiopathogéniedes maladies parodontales a été le principal obstacle à la recherche d'un vaccin.Parmi les quelque 300 espèces de bactéries présentes dans la plaque sous-gingivale, 5 à 7 espèces ont étéimpliquées dans l'étiologie de la parodontite et pourraient jouer un rôle important en tant qu'agents pathogènes primaires.Une nouvelle étape a été franchie après que les agents pathogènes primaires, Porphyromonas gingivaliset Actinobacillus actinomycetemcomitans, ont...
La recherche de vaccins contre les maladies parodontales en est encore à ses débuts. La complexité de l'étiopathogéniedes maladies parodontales a...
Periodontitis is denoted by the destruction of connective tissue, loss of periodontal attachment and resorption of alveolar bone. The tissue destruction in periodontal disease appears as a result of the interaction between the pathogenic microflora and the host's immune and inflammatory responses. The immune system is activated in order to protect against local microbial attack and their damaging products from spreading or invading the gingival tissues
Periodontitis is denoted by the destruction of connective tissue, loss of periodontal attachment and resorption of alveolar bone. The tissue destructi...
