Type 2 diabetes (T2DM) is one of the most prevalent health problems in the twenty-first century, this great spread is due to several factors, including obesity. In this disease, the body can produce insulin, but it does not work as normal, and this leads to a high level of glucose in the blood. In addition to that, nanotechnology is the most important modern technologies and is used in several areas. This study was carried out to determine the relation insulin with its receptor and calculation insulin resistance in sera of patients with T2DM at different stages of BMI, and evaluate the impact...