The contaminated root canal is a great source of aerobic, anaerobic, gram-positive and gram-negative bacteria and therefore endodontic infections are considered to be polymicrobial in nature. Microbial infection of root canal is the major reason behind the inflammatory reaction of periapical tissues which leads to apical periodontitis. Chemo mechanical preparation is considered as the prime procedure in endodontic treatment. Anatomical complexities and microbiological factors often pose serious threats to adequate root canal disinfection. It is a prerequisite to use endodontic irrigants in...