Nephrotic syndrome is the clinical manifestation of glomerular diseases associated with heavy (nephrotic-range) proteinuria. Nephrotic range proteinuria is defined as proteinuria >3.5 g/24 hr or a urine protein : creatinine ratio >2. The triad of clinical findings associated with nephrotic syndrome arising from the large urinary losses of protein are hypoalbuminemia ( 2.5 g/dL), edema, and hyperlipidemia (cholesterol >200 mg/dL). Infection is a major complication in children with Nephrotic syndrome. Patients with relapse will have increased susceptibility to bacterial infection because of...

Le syndrome néphrotique est la manifestation clinique de maladies glomérulaires associées à une forte protéinurie (de type néphrotique). La protéinurie de type néphrotique est définie comme une protéinurie >3,5 g/24 h ou un rapport protéines urinaires/créatinine >2. La triade d'observations cliniques associées au syndrome néphrotique et résultant des importantes pertes urinaires de protéines est l'hypoalbuminémie ( 2,5 g/dL), l'oedème et l'hyperlipidémie (cholestérol >200 mg/dL).Le syndrome néphrotique touche 1-3 enfants sur 100 000 âgés de moins de 16 ans. Sans...

Nephrotic syndrome is the clinical manifestation of glomerular diseases associated with heavy (nephrotic-range) proteinuria. Nephrotic range proteinuria is defined as proteinuria >3.5 g/24 hr or a urine protein : creatinine ratio >2. The triad of clinical findings associated with nephrotic syndrome arising from the large urinary losses of protein are hypoalbuminemia ( 2.5 g/dL), edema, and hyperlipidemia (cholesterol >200 mg/dL).Nephrotic syndrome affects 1-3 per 100,000 children <16 yr of age. Without treatment, nephrotic syndrome in children is associated with a high risk of death, most...