Birth is about a sixteen year old girl named Zoey, who is one of the few people with a very special trait. She has a spirit animal that was born on her sixteenth birthday, a mythological creature by the name of Ambrose. As they are learning how to cope with this new situation, Zoey meets Alice and her lion spirit animal, Kenway. Then Chase and his bird spirit animal, Valerie, come crashing on the scene from a different reality. With their combined strength and the help of Oliver and his horse spirit animal, Garret, they take on the secret corporation GCRF.