Growing up a privileged Manhattan kid, Jeff Nichols should have had it all. Instead, he got a plethora of impairments: learning disabilities, a speech impediment, dyslexia, ADD, and a mild case of Tourette's syndrome.

In Trainwreck, his weird and witty memoir of utter dysfunction, Nichols gives an irreverent look at how one "idoit" made good. Bounced from elite private schools, he limps through college, earning the nickname "Iron Lung" for his uncanny ability to inhale from a four-foot bong without coughing. By the skin of his teeth, he graduates and lands a job on Wall...