Detective quantum efficiency (DQE) is widely accepted as the golden rule to objectively evaluate the performance of x-ray imaging systems. It provides a comprehensive characterization of an x-ray imaging system, because it combines several important image-quality-related measurements such as contrast, resolution, and noise, and because it measures the efficiency of the utilization of x-ray in the imaging process. Despite its importance, the current DQE methodology is imperfect in general agreement. The focus of this dissertation is to investigate the DQE methodology for digital x-ray imaging...