Nalidixic acid-Tryptophan conjugate was synthesized by coupling Nalidixic acid with glycine methyl ester hydrochloride and characterized by melting point, thin layer chromatography, RM value, scanning electron microscopy, x-ray diffraction study and high performance liquid chromatography. The structure of prodrug was confirmed by analytical techniques, elemental analysis, fourier transform infrared spectroscopy, fourier transform nuclear magnetic resonance spectroscopy and mass spectroscopy. Preformulation studies revealed increased aqueous solubility with non significant change in...