Microspheres made from lipids and polymers provide an interesting opportunity for use as drug delivery vehicles for numerous therapeutics that can range in size from small molecules to macromolecules like peptide/protein. In addition, cationization on the lipid-based microsphere systems has tremendous application for drug absorption enhancement and for ferrying compounds across cell membranes. Surely excipients play an important role not only to make an acceptable microsphere product but also to minimize/prevent the degradation of the incorporated drug molecules. Special emphasis is being...

Highlighting the use of colloidal dispersions as eyedrop formulations containing single or dual drugs has garnered significant interest. This book covers the development of formulas, preclinical safety evaluation, and animal studies for single drug-loaded emulsion eyedrops. It explains how to convert liquid-retentive eyedrops into solid-dry powder for reconstitution, prolonging colloidal stability. Applying a polymer coat to dispersed oil droplets forms nanocapsules, extending drug release in nanocapsule-based eyedrops. The book elucidates two-compartment formation in nanocapsules and...