Chordoma is a rare malignant bone tumour, showing notochordal differentiation and occurs in the axial skeleton. Brachyury, a molecule involved in notochordal development, is a highly specific and sensitive marker for chordoma. It is hypothesised that brachyury or genes involved in its activation are implicated in the pathogenesis of chordoma. As there is no effective drug therapy for chordoma, the aim was to identify genetic events involved in chordoma pathogenesis with a view to identifying potential therapeutic targets. PI3K/AKT/TSC/mTOR pathway was found activated in 65% of chordomas,...