The present study was planned to construct the conjugate ofFc fragment of mice IgG with rOMP 28. The developed conjugate wasused to investigate the kinetics of humoral and cellular immuneresponse in comparison to its un conjugated and the rOMP 28 alone.Among all the groups, the group of mice immunized with CpG+ rOMP 28 induced highest level of humoral immune response andBrucella abortus S19 group conferred highest level of cellular response which was evidenced by high nitric oxide concentration and also by the clearance of virulent B. abortus 544 from the spleen after challenge.The conjugated...