The aims of the present study were, first: to demonstrate the efficacy of new candidate tinidazole against Echinococcus granulosus by using in vitro model, second: testing what are the metabolic pathway chemotherapeutic targets in E. granulosus for the traditional antiparasitic drugs used?, and third: as an attempt to verify aspects on hydatid cyst membrane permeability to drugs. Besides demonstrating morphological alterations, assessing viability of E. granulosus protoscolices, and calculating of ED50 value, HPLC was used to obtain the information on the actual drug concentration within the...

Benzodiazepines (BZs) were reported to protect against ethanol-induced gastric damage in rat s in vivo and in vitro model. However, the effects of some drugs in the new in vitro model do not agree with the results reported before in vivo studies. Therefore, the present study was designed to modify the new in vitro model and to assess the gastroprotective effects of some BZs, and also some new compounds. Gastric mucosal damage was induced by instillation of ethanol into the isolated rat stomach kept in aerated Kreb s solution at 37°C in an organ bath. Drugs or their vehicles were administered...