Pharmacokinetic and bio-equivalency studies require very precise and accurate assay methods that are well-validated to quantify drugs in biological samples. The assay methods have to be sensitive enough to determine the biological sample concentration of the drug and/or its metabolite(s) for a period of about five elimination half-lives after the dosage of the drug. The assay methods also have to be very selective to ensure reliable data, free from the interference of endogenous98 compounds in the biological samples. In addition, methods have to be as robust and cost-effective as possible,...

Bioanalysis of drug substance and drug product is a subdiscipline of analytical chemistry for the quantitative determination of drugs in biological matrix such as whole blood, plasma, serum, tissue and urine. It has witnessed a remarkable flow, both in the development of more selective and effective drugs and in understanding their therapeutic and toxic effects. Knowledge of drug levels in body fluids allows the optimization of pharmacotherapy and provides a basis for the evaluation and interpretation of patient compliance, bioavailability, bioequivalence and pharmacokinetics. Pharmacokinetic...

Recent advances in wireless sensor networks (WSNs) have led to many new promising applications including habitat monitoring and target tracking. Secure Routing is one of the important issues in wireless sensor networks. Several approaches have been proposed for secure routing in wireless sensor networks, but there is a lack of sufficient support for quick & secure routing in large-scale sensor networks. These networks are easily prone to security attacks since once deployed these networks are unattended and unprotected. Some of the inherent features like limited battery and low memory make...

Benzimidazole derivatives are potent pharmaceutical agents due to their therapeutic applications such as anticancer, analgesic, hypotensive, neuroprotective, antidiabetic, etc. Benzimidazole is one of the privileged scaffolds for drug design and discovery. Currently, we have designed, synthesized and characterized benzimidazole clubbed pyrazoline derivatives from 2-mercapto benzimidazole. These derivatives have been investigated for their antimicrobial activities as well as antioxidant activities. In silico molecular docking of all novel compounds was carried out to ensure their potential as...

Les dérivés du benzimidazole sont des agents pharmaceutiques puissants en raison de leurs applications thérapeutiques telles que l'anticancéreux, l'analgésique, l'hypotenseur, le neuroprotecteur, l'antidiabétique, etc. Le benzimidazole est l'un des échafaudages privilégiés pour la conception et la découverte de médicaments. Actuellement, nous avons conçu, synthétisé et caractérisé des dérivés de la pyrazoline à club benzimidazole à partir du 2-mercapto benzimidazole. Ces dérivés ont été étudiés pour leurs activités antimicrobiennes et antioxydantes. Le docking...

Benzimidazol-Derivate sind aufgrund ihrer therapeutischen Anwendungen wie Krebsbekämpfung, Analgetika, blutdrucksenkende Mittel, neuroprotektive Mittel, Antidiabetika usw. potente Arzneimittel. Benzimidazol ist eines der bevorzugten Gerüste für die Entwicklung und Entdeckung von Arzneimitteln. Derzeit haben wir Benzimidazol-Pyrazolin-Derivate aus 2-Mercapto-Benzimidazol entwickelt, synthetisiert und charakterisiert. Diese Derivate wurden auf ihre antimikrobielle und antioxidative Wirkung untersucht. Für alle neuen Verbindungen wurde ein In-silico-Molekular-Docking durchgeführt, um ihr...