Morsi, Nadia, Abdou Badie, Hany, Abdel Rahman El Shakhs, Suzan
Nasal route for drug administration has an advantage of introducing the drug directly into the systemic circulation without passing through the liver so it eliminates the first pass effect. In addition to its high absorptive surface, rich circulation which increases both rate and extend of drug absorption. Bioadhesive gel is an ideal dosage form for the nasal route as it keeps the drug in contact with the nasal mucosa for prolonged time by decreasing the nasal mucocillary clearance so elongates the nasal residence time allowing for increased absorption and increased bioavailability....
Nasal route for drug administration has an advantage of introducing the drug directly into the systemic circulation without passing through the liver ...
